DMRforPairs: identifying differentially methylated regions between unique samples using array based methylation profiles.

ABSTRACT:

Background

Array based methylation profiling is a cost-effective solution to study the association between genome methylation and human disease & development. Available tools to analyze the Illumina Infinium HumanMethylation450 BeadChip focus on comparing methylation levels per locus. Other tools combine multiple probes into a range, identifying differential methylated regions (DMRs). These tools all require groups of samples to compare. However, comparison of unique, individual samples is essential in situations where larger sample sizes are not possible.

Results

DMRforPairs was designed to compare regional methylation status between unique samples. It identifies probe dense genomic regions and quantifies/tests their (difference in) methylation level between the samples. As

SUBMITTER: Rijlaarsdam MA 

PROVIDER: S-EPMC4046028 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature