Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers.

ABSTRACT:

Objective

To investigate the relationship between inflammatory [interleukin-6 (IL-6) and C-reactive protein (CRP)] and coagulation (D-dimer) biomarkers and cancer risk during HIV infection.

Design

A prospective cohort.

Methods

HIV-infected patients on continuous antiretroviral therapy (ART) in the control arms of three randomized trials (N=5023) were included in an analysis of predictors of cancer (any type, infection-related or infection-unrelated). Hazard ratios for IL-6, CRP and D-dimer levels (log2-transformed) were calculated using Cox models stratified by trial and adjusted for demographics and CD4+ cell counts and adjusted also for all biomarkers simultaneously. To assess the possibility that biomarker levels were elevated at entry due to undiagnosed cancer, an

SUBMITTER: Borges AH 

PROVIDER: S-EPMC4046103 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature