Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats.

ABSTRACT:

Objectives

In insulin resistance, the insulin action in liver, muscles and adipocytes decreases and result in hyperglycemia, dyslipidemia and hyperinsulinemia. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats.

Materials and methods

Experimental rats were fed with high fructose diet for 6 weeks and then were treated with Z. multiflora extract or a pioglitazone solution for 2 weeks. Blood and tissue samples were collected for analysis at the end of two weeks. Blood glucose, serum level of triglyceride and cholesterol were measured by auto analyzer. Insulin and adiponectin levels were assayed by en

SUBMITTER: Mohammadi A 

PROVIDER: S-EPMC4046234 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature