Severity of obstructive sleep apnea influences the effect of genotype on response to anti-arrhythmic drug therapy for atrial fibrillation.

ABSTRACT:

Study objectives

To examine the impact of genotype on the relationship between obstructive sleep apnea (OSA) and anti-arrhythmic drug (AAD) efficacy in atrial fibrillation (AF).

Design

Registry based.

Setting

Clinic-based.

Participants

Eighty-four individuals from Vanderbilt AF registry who had polysomnography, genotyping, and serial comprehensive evaluations of AF status.

Interventions

None.

Measurements and results

Response to AADs was defined as a decrease in AF burden score by ≥ 75% or the combination of sinus rhythm on follow-up EKGs, stable AAD therapy for at least 6 months, objective AF burden below an established threshold, and the absence of non-pharmacologic therapies. Participants were genotyped for common AF susceptibility alleles at c

SUBMITTER: Goyal SK 

PROVIDER: S-EPMC4046365 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature