In silico and Ex vivo approaches identify a role for toll-like receptor 4 in colorectal cancer.

ABSTRACT:

Background

Inflammation increases the risk of colorectal cancer (CRC). We and others have described a role for TLR4, the receptor for LPS, in colon cancer. To explore the relationships between TLR4 expression and CRC, we combined the strength of transcriptome array data and immunohistochemical (IHC) staining.

Methods

TLR4 signal intensity was scored in the stromal and epithelial compartments. Detection of differential expression between conditions of interest was performed using linear models, Cox proportional hazards models, and empirical Bayes methods.

Results

A strong association between TLR4 expression and survival was noted, though a dichotomous relationship between survival and specific TLR4 transcripts was observed. Increasing TLR4 expression was seen with adva

SUBMITTER: Sussman DA 

PROVIDER: S-EPMC4046523 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature