Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectives.

ABSTRACT: Neurological diseases have placed heavy social and financial burdens on modern society. As the life expectancy of humans is extended, neurological diseases, such as Parkinson's disease, have become increasingly common among senior populations. Although the enigmas of Parkinson's diseases await resolution, more vivid pictures on the cause, progression, and control of the illness are emerging after years of research. On the molecular level, GTPases are implicated in the etiology of Parkinson's disease and are rational pharmaceutical targets for their control. However, targeting individual GTPases, which belong to a superfamily of proteins containing multiple members with a conserved guanine nucleotide binding domain, has proven to be challenging. In contrast, pharmaceutical pursuit of inhibi

SUBMITTER: Hong L 

PROVIDER: S-EPMC4046578 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature