Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis.

ABSTRACT:

Background

Psoriasis is a chronic autoimmune disease in which T cells have a predominant role in initiating and perpetuating the chronic inflammation in skin. However, the mechanisms that regulate T cell activation in psoriasis are still incompletely understood. The objective of the present study was to characterize the main genetic pathways associated with T cell activation in psoriasis.

Results

Gene expression profiles from in vitro activated T cells were obtained from 17 psoriasis patients and 7 healthy controls using Illumina HT-12 v4 microarrays. From a total of 47,321 analyzed transcripts, 42 genes were found to be differentially expressed between psoriasis and controls (FDR p-value < 0.1, absolute fold-change > 1.2). Using an independent cohort of 8 patients and 8 hea

SUBMITTER: Palau N 

PROVIDER: S-EPMC4046651 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature