Prioritizing genes responsible for host resistance to influenza using network approaches.

ABSTRACT:

Background

The genetic make-up of humans and other mammals (such as mice) affects their resistance to influenza virus infection. Considering the complexity and moral issues associated with experiments on human subjects, we have only acquired partial knowledge regarding the underlying molecular mechanisms. Although influenza resistance in inbred mice has been mapped to several quantitative trait loci (QTLs), which have greatly narrowed down the search for host resistance genes, only few underlying genes have been identified.

Results

To prioritize a list of promising candidates for future functional investigation, we applied network-based approaches to leverage the information of known resistance genes and the expression profiles contrasting susceptible and resistant mouse str

SUBMITTER: Bao S 

PROVIDER: S-EPMC4046670 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature