Associations of FGF-23 and sKlotho with cardiovascular outcomes among patients with CKD stages 2-4.

ABSTRACT:

Background and objectives

CKD-mineral and bone disorders (CKD-MBD) measures contribute to cardiovascular morbidity in patients with CKD. Among these, fibroblast growth factor (FGF)-23 and its coreceptor Klotho may exert direct effects on vascular and myocardial tissues. Klotho exists in a membrane-bound and a soluble form (sKlotho). Recent experimental evidence suggests sKlotho has vasculoprotective functions.

Design, settings, participants, & measurements

Traditional and novel CKD-MBD variables were measured among 444 patients with CKD stages 2-4 recruited between September 2008 and November 2012 into the ongoing CARE FOR HOMe study. Across tertiles of baseline sKlotho and FGF-23, the incidence of two distinct combined end points was analyzed: (1) the first occurrence of an

SUBMITTER: Seiler S 

PROVIDER: S-EPMC4046724 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature