Association of a polymorphism in a gene encoding a urate transporter with CKD progression.

ABSTRACT:

Background and objectives

Hyperuricemia predicts a high risk for CKD progression but there is no large clinical trial in humans indicating that this relationship is causal in nature. The rs734553 single-nucleotide polymorphism (SNP) of the GLUT9 urate transporter gene was strongly associated with uric acid (UA) levels in a large meta-analysis.

Design, setting, participants, & measurements

This prospective study adopted the Mendelian randomization approach. The rs734553 SNP was used as an instrumental variable to investigate the relationship between UA and renal outcomes in a cohort of 755 patients with CKD who were enrolled between October 18, 2005, and October 2, 2008. The association between the polymorphism and UA was preliminary confirmed in a series of 211 healthy volun

SUBMITTER: Testa A 

PROVIDER: S-EPMC4046734 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature