Calcium phosphate thin films enhance the response of human mesenchymal stem cells to nanostructured titanium surfaces.

ABSTRACT: The development of biomaterial surfaces possessing the topographical cues that can promote mesenchymal stem cell recruitment and, in particular, those capable of subsequently directing osteogenic differentiation is of increasing importance for the advancement of tissue engineering. While it is accepted that it is the interaction with specific nanoscale topography that induces mesenchymal stem cell differentiation, the potential for an attendant bioactive chemistry working in tandem with such nanoscale features to enhance this effect has not been considered to any great extent. This article presents a study of mesenchymal stem cell response to conformal bioactive calcium phosphate thin films sputter deposited onto a polycrystalline titanium nanostructured surface with proven capability to d

SUBMITTER: McCafferty MM 

PROVIDER: S-EPMC4046794 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature