Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia.

ABSTRACT: In the present study, an integrated hierarchical approach was applied to: (1) identify pathways associated with susceptibility to schizophrenia; (2) detect genes that may be potentially affected in these pathways since they contain an associated polymorphism; and (3) annotate the functional consequences of such single-nucleotide polymorphisms (SNPs) in the affected genes or their regulatory regions. The Global Test was applied to detect schizophrenia-associated pathways using discovery and replication datasets comprising 5,040 and 5,082 individuals of European ancestry, respectively. Information concerning functional gene-sets was retrieved from the Kyoto Encyclopedia of Genes and Genomes, Gene Ontology, and the Molecular Signatures Database. Fourteen of the gene-sets or pathways identifie

SUBMITTER: Juraeva D 

PROVIDER: S-EPMC4046913 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature