Histone modifications are associated with transcript isoform diversity in normal and cancer cells.

ABSTRACT: Mechanisms that generate transcript diversity are of fundamental importance in eukaryotes. Although a large fraction of human protein-coding genes and lincRNAs produce more than one mRNA isoform each, the regulation of this phenomenon is still incompletely understood. Much progress has been made in deciphering the role of sequence-specific features as well as DNA-and RNA-binding proteins in alternative splicing. Recently, however, several experimental studies of individual genes have revealed a direct involvement of epigenetic factors in alternative splicing and transcription initiation. While histone modifications are generally correlated with overall gene expression levels, it remains unclear how histone modification enrichment affects relative isoform abundance. Therefore, we sought to

SUBMITTER: Podlaha O 

PROVIDER: S-EPMC4046914 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature