Plasma Septin9 versus fecal immunochemical testing for colorectal cancer screening: a prospective multicenter study.

ABSTRACT:

Background

Screening improves outcomes related to colorectal cancer (CRC); however, suboptimal participation for available screening tests limits the full benefits of screening. Non-invasive screening using a blood based assay may potentially help reach the unscreened population.

Objective

To compare the performance of a new Septin9 DNA methylation based blood test with a fecal immunochemical test (FIT) for CRC screening.

Design

In this trial, fecal and blood samples were obtained from enrolled patients. To compare test sensitivity for CRC, patients with screening identified colorectal cancer (n = 102) were enrolled and provided samples prior to surgery. To compare test specificity patients were enrolled prospectively (n = 199) and provided samples prior to bowel prep

SUBMITTER: Johnson DA 

PROVIDER: S-EPMC4046970 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature