Gastrointestinal endogenous proteins as a source of bioactive peptides--an in silico study.

ABSTRACT: Dietary proteins are known to contain bioactive peptides that are released during digestion. Endogenous proteins secreted into the gastrointestinal tract represent a quantitatively greater supply of protein to the gut lumen than those of dietary origin. Many of these endogenous proteins are digested in the gastrointestinal tract but the possibility that these are also a source of bioactive peptides has not been considered. An in silico prediction method was used to test if bioactive peptides could be derived from the gastrointestinal digestion of gut endogenous proteins. Twenty six gut endogenous proteins and seven dietary proteins were evaluated. The peptides present after gastric and intestinal digestion were predicted based on the amino acid sequence of the proteins and the known specif

SUBMITTER: Dave LA 

PROVIDER: S-EPMC4047039 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature