SOX2+ cell population from normal human brain white matter is able to generate mature oligodendrocytes.

ABSTRACT:

Objectives

A number of neurodegenerative diseases progress with a loss of myelin, which makes them candidate diseases for the development of cell-replacement therapies based on mobilisation or isolation of the endogenous neural/glial progenitor cells, in vitro expansion, and further implantation. Cells expressing A2B5 or PDGFRA/CNP have been isolated within the pool of glial progenitor cells in the subcortical white matter of the normal adult human brain, all of which demonstrate glial progenitor features. However, the heterogeneity and differentiation potential of this pool of cells is not yet well established.

Methods

We used diffusion tensor images, histopathology, and immunostaining analysis to demonstrate normal cytoarchitecture and the absence of abnormalities in human

SUBMITTER: Oliver-De La Cruz J 

PROVIDER: S-EPMC4047120 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature