SpliceVista, a tool for splice variant identification and visualization in shotgun proteomics data.

ABSTRACT: Alternative splicing is a pervasive process in eukaryotic organisms. More than 90% of human genes have alternatively spliced products, and aberrant splicing has been shown to be associated with many diseases. Current methods employed in the detection of splice variants include prediction by clustering of expressed sequence tags, exon microarray, and mRNA sequencing, all methods focusing on RNA-level information. There is a lack of tools for analyzing splice variants at the protein level. Here, we present SpliceVista, a tool for splice variant identification and visualization based on mass spectrometry proteomics data. SpliceVista retrieves gene structure and translated sequences from alternative splicing databases and maps MS-identified peptides to splice variants. The visualization module

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC4047474 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature