Dynamic equilibrium of heterogeneous and interconvertible multipotent hematopoietic cell subsets.

ABSTRACT: Populations of hematopoietic stem cells and progenitors are quite heterogeneous and consist of multiple cell subsets with distinct phenotypic and functional characteristics. Some of these subsets also appear to be interconvertible and oscillate between functionally distinct states. The multipotent hematopoietic cell line EML has emerged as a unique model to study the heterogeneity and interconvertibility of multipotent hematopoietic cells. Here we describe extensive phenotypic and functional heterogeneity of EML cells which stems from the coexistence of multiple cell subsets. Each of these subsets is phenotypically and functionally heterogeneous, and displays distinct multilineage differentiation potential, cell cycle profile, proliferation kinetics, and expression pattern of HSC markers a

SUBMITTER: Weston W 

PROVIDER: S-EPMC4047531 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature