Association between STAT3 gene polymorphisms and Crohn's disease susceptibility: a case-control study in a Chinese Han population.

ABSTRACT:

Background

Crohn's disease (CD) is an immune-related disease with genetic predisposition. This study aimed to investigate the association of three polymorphisms in the signal transducer and activator of transcription 3 (STAT3) gene with CD risk in a Chinese population.

Methods

We conducted a hospital-based case-control study involving 232 CD patients and 272 controls. Genotyping was performed using polymerase chain reaction with sequence-specific primer method. Statistical analyses were conducted using logistic regression and genotype risk scoring.

Results

Significant differences were found between patients and controls in allele/genotype distributions of rs744166 (Pallele=0.0008; Pgenotype=0.003) and allele distributions of rs4796793 (P = 0.03). The risk for CD assoc

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4047544 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature