'Click cyclic ADP-ribose': a neutral second messenger mimic.

ABSTRACT: Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.

SUBMITTER: Swarbrick JM 

PROVIDER: S-EPMC4047616 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature