Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.

ABSTRACT:

Rationale

The emergence of lymphatic endothelial cells (LECs) seems to be highly regulated during development. Although several factors that promote the differentiation of LECs in embryonic development have been identified, those that negatively regulate this process are largely unknown.

Objective

Our aim was to delineate the role of bone morphogenetic protein (BMP) 2 signaling in lymphatic development.

Methods and results

BMP2 signaling negatively regulates the formation of LECs. Developing LECs lack any detectable BMP signaling activity in both zebrafish and mouse embryos, and excess BMP2 signaling in zebrafish embryos and mouse embryonic stem cell-derived embryoid bodies substantially decrease the emergence of LECs. Mechanistically, BMP2 signaling induces expressio

SUBMITTER: Dunworth WP 

PROVIDER: S-EPMC4047637 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature