Hypoperfusion intensity ratio predicts infarct progression and functional outcome in the DEFUSE 2 Cohort.

ABSTRACT:

Background and purpose

We evaluate associations between the severity of magnetic resonance perfusion-weighted imaging abnormalities, as assessed by the hypoperfusion intensity ratio (HIR), on infarct progression and functional outcome in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study 2 (DEFUSE 2).

Methods

Diffusion-weighted magnetic resonance imaging and perfusion-weighted imaging lesion volumes were determined with the RAPID software program. HIR was defined as the proportion of TMax >6 s lesion volume with a Tmax >10 s delay and was dichotomized based on its median value (0.4) into low versus high subgroups as well as quartiles. Final infarct volumes were assessed at day 5. Initial infarct growth velocity was calculated as the basel

SUBMITTER: Olivot JM 

PROVIDER: S-EPMC4047639 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature