Properties of newly-synthesized cationic semi-interpenetrating hydrogels containing either hyaluronan or chondroitin sulfate in a methacrylic matrix.

ABSTRACT: Extracellular matrix components such as hyaluronan (HA) and chondroitin sulfate (CS) were combined with a synthetic matrix of p(HEMA-co-METAC) (poly(2-hydroxyethylmethacrylate-co-2-methacryloxyethyltrimethylammonium)) at 1% and 2% w/w concentration following a previously developed procedure. The resulting semi-interpenetrating hydrogels were able to extensively swell in water incrementing their dry weight up to 13 fold depending on the glycosamminoglycan content and nature. When swollen in physiological solution, materials water uptake significantly decreased, and the differences in swelling capability became negligible. In physiological conditions, HA was released from the materials up to 38%w/w while CS was found almost fully retained. Materials were not cytotoxic and a biological evalua

SUBMITTER: Gatta AL 

PROVIDER: S-EPMC4047938 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature