HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases.

ABSTRACT:

Background

Various kinds of autoimmune diseases have been reported to have a significant relationship with persistent hepatitis c virus (HCV) infection and Th17 cells. Previously, our group reported that the existence of HCV in T lymphocytes could affect the development of CD4+ helper T cells and their proliferation, in addition to the induction of immunoglobulin hyper-mutation.

Methods

Therefore, we analyzed the relationship between persistent infection of HCV and the mechanism of Th17 cell induction ex vivo and in vitro.

Results

The prevalence of autoimmune-related diseases in chronic hepatitis c patients (CH-C) was significantly higher than in other types of chronic hepatitis (hepatitis B and NASH). A significantly higher frequency of IL6 and TGF-β double-high pati

SUBMITTER: Kondo Y 

PROVIDER: S-EPMC4048196 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature