Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function.

ABSTRACT: As pleiotropic coregulators, members of the p160/steroid receptor coactivator (SRC) family control a broad spectrum of transcriptional responses that underpin a diverse array of physiological and pathophysiological processes. Because of their potent coregulator properties, strict controls on SRC expression levels are required to maintain normal tissue functionality. Accordingly, an unwarranted increase in the cellular levels of SRC members has been causally linked to the initiation and/or progression of a number of clinical disorders. Although knockout mouse models have underscored the critical non-redundant roles for each SRC member in vivo, there are surprisingly few mouse models that have been engineered to overexpress SRCs. This deficiency is significant since SRC involvement in many o

SUBMITTER: Szwarc MM 

PROVIDER: S-EPMC4048228 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature