Newborns of obese parents have altered DNA methylation patterns at imprinted genes.

ABSTRACT:

Background

Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed to epigenetic changes, such as DNA methylation shifts at imprinted genes, little is known about the potential effects of maternal and paternal preconceptional overnutrition or obesity.

Objective

We examined parental preconceptional obesity in relation to DNA methylation profiles at multiple human imprinted genes important in normal growth and development, such as: maternally expressed gene 3 (MEG3), mesoderm-specific transcript (MEST), paternally expressed gene 3 (PEG3), pleiomorphic adenoma gene-like 1 (PLAGL1), epsilon sarcoglycan and pat

SUBMITTER: Soubry A 

PROVIDER: S-EPMC4048324 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature