Lack of association of INS VNTR polymorphism with polycystic ovary syndrome: a meta-analysis.

ABSTRACT:

Purpose

An association between the INS VNTR polymorphisms and polycystic ovary syndrome (PCOS) susceptibility has been reported in previous studies, but the results were inconsistent. This study was conducted to explore this association using meta-analysis.

Methods

PubMed, Embase, and China National Knowledge Infrastructure (CNKI) were searched according to predefined criteria for all relevant studies published up to August 2013. Four genetic models, together with odds ratios (ORs) and 95 % confidence intervals (CI), were calculated. Subgroup analyses were performed by ethnicity, anovulatory PCOS, and Hardy-Weinberg equilibrium (HWE) in the controls.

Results

In total, 13 case-control studies, including 1,767 cases and 4,108 controls, were included. No significant asso

SUBMITTER: Song LY 

PROVIDER: S-EPMC4048387 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature