Complement activation in multiple sclerosis plaques: an immunohistochemical analysis.

ABSTRACT:

Introduction

Inflammation and complement activation are firmly implicated in the pathology of multiple sclerosis; however, the extent and nature of their involvement in specific pathological processes such as axonal damage, myelin loss and disease progression remains uncertain. This study aims to bring clarity to these questions.

Results

We describe a detailed immunohistochemical study to localise a strategically selected set of complement proteins, activation products and regulators in brain and spinal cord tissue of 17 patients with progressive multiple sclerosis and 16 control donors, including 9 with central nervous system disease. Active, chronic active and chronic inactive multiple sclerosis plaques (35 in total) and non-plaque areas were examined.Multiple sclerosis pl

SUBMITTER: Ingram G 

PROVIDER: S-EPMC4048455 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature