Association of Hepatitis C Virus Infection and Interleukin-28B Gene Polymorphism in Chinese Children.

ABSTRACT:

Objective

To preliminarily explore the association of rs12979860 and rs8099917 SNPs with chronic HCV infection in Chinese Han children.

Methods

Chronic HCV infection patients (n=277; 1-17 years old, 4.5 years old in average) and healthy subjects (n=150, children; 2-17 years old, 5.2 years old in average) were recruited and tested by PCR combining direct sequencing. The differences between the rs12979860 and rs8099917 genotypes in patients and healthy subjects were compared.

Results

The genetic variations at rs12979860 and rs8099917 in chronic hepatitis C (CHC) children and healthy subjects did not differ significantly. The frequency of spontaneous clearance in CHC children was higher (47%), which is related to the genetic variations. The histological changes of patien

SUBMITTER: Wu RR 

PROVIDER: S-EPMC4048498 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature