Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula.

ABSTRACT:

Background

Somatic complaints and altered interoceptive awareness are common features in the clinical presentation of major depressive disorder (MDD). Recently, neurobiological evidence has accumulated demonstrating that the insula is one of the primary cortical structures underlying interoceptive awareness. Abnormal interoceptive representation within the insula may thus contribute to the pathophysiology and symptomatology of MDD.

Methods

We compared functional magnetic resonance imaging blood oxygenation level-dependent responses between 20 unmedicated adults with MDD and 20 healthy control participants during a task requiring attention to visceral interoceptive sensations and also assessed the relationship of this blood oxygenation level-dependent response to depression s

SUBMITTER: Avery JA 

PROVIDER: S-EPMC4048794 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature