Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx.

ABSTRACT: Bone formation is a developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osterix (Osx) is an osteoblast-specific transcription factor required for bone formation and osteoblast differentiation. Previous observation that Osx inhibits Wnt signaling pathway provides a novel concept of feedback control mechanisms involved in bone formation. Wnt antagonist Dickkopf-1 (Dkk1) plays an important role on skeletal development and bone remodeling. Osx has been shown to activate the Dkk1 promoter; however, the detailed mechanism of Osx regulation on Dkk1 expression is not fully understood. In this study, quantitative real-time RT-PCR results demonstrated that Dkk1 expression was downregulated in Osx-null calvaria at two different points of E15.5 and E18.5 in mi

SUBMITTER: Zhang C 

PROVIDER: S-EPMC4048943 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature