Myxomatous mitral valve disease bench to bedside: LDL-density-pressure regulates Lrp5.

ABSTRACT: The myxomatous mitral valve is the most common form of valvular heart disease. The pathologic presentation of myxomatous mitral valve disease varies between valve thickness, degree of leaflet prolapse and the presence or absence of flail leaflets. Recent molecular biology studies have confirmed that the myxomatous changes in mitral valve prolapse equals a cartilage phenotype, which is regulated by the Lrp5 receptor. Clinically, echocardiography defines the valve pathology to determine the surgical approach to valve repair or replacement. Furthermore, the timing of surgical valve repair is controversial and is the subject of a current multicenter trial. The results will resolve the timing of whether watchful waiting versus early surgical valve repair decreases morbidity and mortality of thi

SUBMITTER: Rajamannan NM 

PROVIDER: S-EPMC4048944 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature