Ontology highlight
ABSTRACT:
SUBMITTER: Cebrian C
PROVIDER: S-EPMC4049224 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cell reports 20140320 1
Nephrons, the functional units of the kidney, develop from progenitor cells (cap mesenchyme [CM]) surrounding the epithelial ureteric bud (UB) tips. Reciprocal signaling between UB and CM induces nephrogenesis and UB branching. Although low nephron number is implicated in hypertension and renal disease, the mechanisms that determine nephron number are obscure. To test the importance of nephron progenitor cell number, we genetically ablated 40% of these cells, asking whether this would limit kidn ...[more]