Optimizing cardiac resynchronization therapy to minimize ATP consumption heterogeneity throughout the left ventricle: a simulation analysis using a canine heart failure model.

ABSTRACT:

Background

Cardiac resynchronization therapy (CRT) has been demonstrated to lead to restoration of oxygen consumption homogeneity throughout the left ventricle (LV), which is important for long-term reverse remodeling of the ventricles. However, research has focused exclusively on identifying the LV pacing sites that led to acute hemodynamic improvements. It remains unclear whether there exist LV pacing sites that could both improve the hemodynamics and result in ATP consumption homogeneity throughout the LV, thus maximizing both CRT short-term and long-term benefits.

Objective

The purpose of this study was to demonstrate the feasibility of optimizing CRT pacing locations to achieve maximal improvement in both ATPCTHI (an ATP consumption heterogeneity index) and stroke work.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC4049272 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature