Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neurons.

ABSTRACT:

Background

Synapse formation occurs when synaptogenic signals trigger coordinated development of pre and postsynaptic structures. One of the best-characterized synaptogenic signals is trans-synaptic adhesion. However, it remains unclear how synaptic proteins are recruited to sites of adhesion. In particular, it is unknown whether synaptogenic signals attract synaptic vesicle (SV) and active zone (AZ) proteins to nascent synapses or instead predominantly function to create sites that are capable of forming synapses. It is also unclear how labile synaptic proteins are at developing synapses after their initial recruitment. To address these issues, we used long-term, live confocal imaging of presynaptic terminal formation in cultured cortical neurons after contact with the synaptogeni

SUBMITTER: Bury LA 

PROVIDER: S-EPMC4049477 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature