Ontology highlight
ABSTRACT:
SUBMITTER: Lito P
PROVIDER: S-EPMC4049532 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Cancer cell 20140417 5
MEK inhibitors are clinically active in BRAF(V600E) melanomas but only marginally so in KRAS mutant tumors. Here, we found that MEK inhibitors suppress ERK signaling more potently in BRAF(V600E), than in KRAS mutant tumors. To understand this, we performed an RNAi screen in a KRAS mutant model and found that CRAF knockdown enhanced MEK inhibition. MEK activated by CRAF was less susceptible to MEK inhibitors than when activated by BRAF(V600E). MEK inhibitors induced RAF-MEK complexes in KRAS muta ...[more]