Antihypertensive agents and risk of Parkinson's disease: a nationwide cohort study.

ABSTRACT:

Background and purpose

Hypertension has been associated with Parkinson's disease (PD), but data on antihypertensive drugs and PD are inconclusive. We aim to evaluate antihypertensive drugs for an association with PD in hypertensive patients.

Methods

Hypertensive patients who were free of PD, dementia and stroke were recruited from 2005-2006 using Taiwan National Health Insurance Database. We examined the association between the use of calcium channel blockers (CCBs), angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs) and the incidence of PD using beta-blockers as the reference. Cox regression model with time-varying medication use was applied.

Results

Among 65,001 hypertensive patients with a mean follow-up period of 4.6 years, use

SUBMITTER: Lee YC 

PROVIDER: S-EPMC4049613 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature