Increased macroH2A1.1 expression correlates with poor survival of triple-negative breast cancer patients.

ABSTRACT:

Purpose

Epithelial-Mesenchymal Transition (EMT) features appear to be key events in development and progression of breast cancer. Epigenetic modifications contribute to the establishment and maintenance of cancer subclasses, as well as to the EMT process. Whether histone variants contribute to these transformations is not known. We investigated the relative expression levels of histone macroH2A1 splice variants and correlated it with breast cancer status/prognosis/types.

Methods

To detect differential expression of macroH2A1 variant mRNAs in breast cancer cells and tumor samples, we used the following databases: GEO, EMBL-EBI and publisher databases (may-august 2012). We extracted macroH2A1.1/macroH2A1 mRNA ratios and performed correlation studies on intrinsic molecular subc

SUBMITTER: Lavigne AC 

PROVIDER: S-EPMC4049614 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature