Assessment of the potential diagnostic value of serum p53 antibody for cancer: a meta-analysis.

ABSTRACT:

Background

Mutant p53 protein over-expression has been reported to induce serum antibodies against p53. We assessed the diagnostic precision of serum p53 (s-p53) antibodies for diagnosis of cancer patients and compared the positive rates of the s-p53 antibody in different types of cancers.

Methods

We systematically searched PubMed and Embase, through May 31, 2012. Studies were assessed for quality using QUADAS (quality assessment of studies of diagnostic accuracy). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were pooled separately and compared with overall accuracy measures using diagnostic odds ratios (DORs) and Area under the curve(AUC). Meta regression and subgroup analyses were done, and heterogeneity and publication bias were assessed.

Res

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4049633 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature