Association between insulin resistance and breast carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women.

Study design

We conducted a systematic review of four databases (PubMed-Medline, EMBASE, Web of Science, and Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using random effects models.

Results

Twenty-two studies (n = 33,405) were selected. Fasting insulin levels were not different between women with and without breast cancer (standardized mean difference, SMD -0.03, 95%CI -0.32 to 0.27; p = 0.9). Similarly, non-fasting/fasting C-peptide levels were not

SUBMITTER: Hernandez AV 

PROVIDER: S-EPMC4049776 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature