First insight into the genotypic diversity of clinical Mycobacterium tuberculosis isolates from Gansu Province, China.

ABSTRACT:

Background

Investigations of Mycobacterium tuberculosis genetic diversity in China have indicated a significant regional distribution. The aim of this study was to characterize the genotypes of clinical M. tuberculosis isolates obtained from Gansu, which has a special geographic location in China.

Methodology/principal findings

A total of 467 clinical M. tuberculosis strains isolated in Gansu Province were genotyped by 15-locus mycobacterial interspersed repetitive units-variable number tandem repeats (MIRU-VNTR) and spoligotyping. The results showed that 445 isolates belonged to six known spoligotype lineages, whereas 22 isolates were unknown. The Beijing genotype was the most prevalent (87.58%, n = 409), while the shared type 1 was the dominant genotype (80.94%, n = 378).

SUBMITTER: Liu J 

PROVIDER: S-EPMC4049826 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature