Motor phenotype of decline in cognitive performance among community-dwellers without dementia: population-based study and meta-analysis.

ABSTRACT:

Background

Decline in cognitive performance is associated with gait deterioration. Our objectives were: 1) to determine, from an original study in older community-dwellers without diagnosis of dementia, which gait parameters, among slower gait speed, higher stride time variability (STV) and Timed Up & Go test (TUG) delta time, were most strongly associated with lower performance in two cognitive domains (i.e., episodic memory and executive function); and 2) to quantitatively synthesize, with a systematic review and meta-analysis, the association between gait performance and cognitive decline (i.e., mild cognitive impairment (MCI) and dementia).

Methods

Based on a cross-sectional design, 934 older community-dwellers without dementia (mean±standard deviation, 70.3±4.9years; 52

SUBMITTER: Beauchet O 

PROVIDER: S-EPMC4049832 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature