Ontology highlight
ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC4050048 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cell metabolism 20140401 4
While obesity represents one of several risk factors for colorectal cancer in humans, the mechanistic underpinnings of this association remain unresolved. Environmental stimuli, including diet, can alter the epigenetic landscape of DNA cis-regulatory elements affecting gene expression and phenotype. Here, we explored the impact of diet and obesity on gene expression and the enhancer landscape in murine colonic epithelium. Obesity led to the accumulation of histone modifications associated with a ...[more]