MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets.

ABSTRACT:

Background

microRNA (miRNA) are important regulators of gene expression. In patients with ischemic stroke we have previously shown that differences in immune cell gene expression are present. In this study we sought to determine the miRNA that are differentially expressed in peripheral blood cells of patients with acute ischemic stroke and thus may regulate immune cell gene expression.

Methods

miRNA from peripheral blood cells of forty-eight patients with ischemic stroke and vascular risk factor controls were compared. Differentially expressed miRNA in patients with ischemic stroke were determined by microarray with qRT-PCR confirmation. The gene targets and pathways associated with ischemic stroke that may be regulated by the identified miRNA were characterized.

Results<

SUBMITTER: Jickling GC 

PROVIDER: S-EPMC4050059 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature