Ontology highlight
ABSTRACT:
SUBMITTER: Kolodziej S
PROVIDER: S-EPMC4050257 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Nature communications 20140529
The transcription factor Tal1 is a critical activator or repressor of gene expression in hematopoiesis and leukaemia. The mechanism by which Tal1 differentially influences transcription of distinct genes is not fully understood. Here we show that Tal1 interacts with the peptidylarginine deiminase IV (PADI4). We demonstrate that PADI4 can act as an epigenetic coactivator through influencing H3R2me2a. At the Tal1/PADI4 target gene IL6ST the repressive H3R2me2a mark triggered by PRMT6 is counteract ...[more]