Outdoor formaldehyde and NO2 exposures and markers of genotoxicity in children living near chipboard industries.

ABSTRACT:

Background

Industrial air pollution is a public health hazard. Previous evidence documented increased respiratory symptoms and hospitalizations in children who live near the factories in the largest chipboard manufacturing district in Italy (Viadana).

Objectives

We evaluated the association of outdoor exposure to formaldehyde and nitrogen dioxide (NO2) with markers of early genotoxic damage in oral mucosa cells of randomly selected children (6-12 years of age) living in Viadana.

Methods

In 2010-2011, DNA strand breaks and nuclear abnormalities were evaluated in exfoliated buccal cells by the comet and micronucleus assays, respectively, and formaldehyde and NO2 were monitored by passive sampling. Annual exposure estimates to pollutants were assigned to children's house

SUBMITTER: Marcon A 

PROVIDER: S-EPMC4050513 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature