Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model.

ABSTRACT: The clinical use of high intensity focused ultrasound (HIFU) therapy for noninvasive tissue ablation has been recently gaining momentum. In HIFU, ultrasound energy from an extracorporeal source is focused within the body to ablate tissue at the focus while leaving the surrounding organs and tissues unaffected. Most HIFU therapies are designed to use heating effects resulting from the absorption of ultrasound by tissue to create a thermally coagulated treatment volume. Although this approach is often successful, it has its limitations, such as the heat sink effect caused by the presence of a large blood vessel near the treatment area or heating of the ribs in the transcostal applications. HIFU-induced bubbles provide an alternative means to destroy the target tissue by mechanical disruption

SUBMITTER: Khokhlova TD 

PROVIDER: S-EPMC4050569 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature