Chromatin fiber polymorphism triggered by variations of DNA linker lengths.

ABSTRACT: Deciphering the factors that control chromatin fiber structure is key to understanding fundamental chromosomal processes. Although details remain unknown, it is becoming clear that chromatin is polymorphic depending on internal and external factors. In particular, different lengths of the linker DNAs joining successive nucleosomes (measured in nucleosome-repeat lengths or NRLs) that characterize different cell types and cell cycle stages produce different structures. NRL is also nonuniform within single fibers, but how this diversity affects chromatin fiber structure is not clear. Here we perform Monte Carlo simulations of a coarse-grained oligonucleosome model to help interpret fiber structure subject to intrafiber NRL variations, as relevant to proliferating cells of interphase chromatin

SUBMITTER: Collepardo-Guevara R 

PROVIDER: S-EPMC4050592 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature