Current developments in understanding of West Nile virus central nervous system disease.

ABSTRACT:

Purpose of review

West Nile virus (WNV) is the most important cause of epidemic encephalitis in the United States. We review articles published in the last 18 months related to the epidemiology, immunology, clinical features, and treatment of this disease.

Recent findings

There was a resurgence in WNV disease in the United States in 2012. The WNV strain now predominant in the United States (NA/WN02) differs from the initial emergent isolate in 1999 (NY99). However, differences in the genetics of currently circulating United States WNV strains do not explain variations in epidemic magnitude or disease severity. Innate and acquired immunity are critical in control of WNV, and in some cases pathways are central nervous system specific. The clinical features of infection are now

SUBMITTER: Tyler KL 

PROVIDER: S-EPMC4050660 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature