Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience.

ABSTRACT: A major limitation in understanding embryonic development is the lack of cell type-specific markers. Existing gene expression and marker atlases provide valuable tools, but they typically have one or more limitations: a lack of single-cell resolution; an inability to register multiple expression patterns to determine their precise relationship; an inability to be upgraded by users; an inability to compare novel patterns with the database patterns; and a lack of three-dimensional images. Here, we develop new 'atlas-builder' software that overcomes each of these limitations. A newly generated atlas is three-dimensional, allows the precise registration of an infinite number of cell type-specific markers, is searchable and is open-ended. Our software can be used to create an atlas of any tissu

SUBMITTER: Heckscher ES 

PROVIDER: S-EPMC4050700 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature